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[HTML][HTML] Apoptosis: A mammalian cell bioprocessing perspective
AL Grilo, A Mantalaris - Biotechnology advances, 2019 - Elsevier
Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …
Optimization and scale up of industrial fermentation processes
FR Schmidt - Applied microbiology and biotechnology, 2005 - Springer
To increase product yields and to ensure consistent product quality, key issues of industrial
fermentations, process optimization and scale up are aimed at maintaining optimum and …
fermentations, process optimization and scale up are aimed at maintaining optimum and …
Scale-down simulators for metabolic analysis of large-scale bioprocesses
P Neubauer, S Junne - Current opinion in biotechnology, 2010 - Elsevier
Analytical approaches for a comprehensive understanding of the metabolic networks in
microbial cultures are mostly based on small-scale cultures which are in a steady state or …
microbial cultures are mostly based on small-scale cultures which are in a steady state or …
CFD simulation of non‐Newtonian fluid flow in anaerobic digesters
B Wu, S Chen - Biotechnology and bioengineering, 2008 - Wiley Online Library
A general mathematical model that predicts the flow fields in a mixed‐flow anaerobic
digester was developed. In this model, the liquid manure was assumed to be a non …
digester was developed. In this model, the liquid manure was assumed to be a non …
Compartmental Modelling in chemical engineering: A critical review
Compartmental modelling is a hybrid way to model complex systems in Chemical
Engineering. This modelling approach offers numerous advantages because it aggregates …
Engineering. This modelling approach offers numerous advantages because it aggregates …
CFD-based compartment model for description of mixing in bioreactors
A Delafosse, ML Collignon, S Calvo, F Delvigne… - Chemical Engineering …, 2014 - Elsevier
In most bioprocesses, it is fundamental to accurately predict the hydrodynamics behavior of
bioreactors of different size and its interaction with the biological reaction. Computational …
bioreactors of different size and its interaction with the biological reaction. Computational …
Modelling local bubble size distributions in agitated vessels
M Laakkonen, P Moilanen, V Alopaeus… - Chemical Engineering …, 2007 - Elsevier
Photography and capillary suction probe were used to measure local bubble size
distributions (BSDs) from Rushton turbine agitated (14/200L) air–tap water and CO2–n …
distributions (BSDs) from Rushton turbine agitated (14/200L) air–tap water and CO2–n …
[HTML][HTML] Digitally enabled approaches for the scale up of mammalian cell bioreactors
MK Alavijeh, I Baker, YY Lee, SL Gras - Digital Chemical Engineering, 2022 - Elsevier
With recent advances in digitisation and big data analytics, more pharmaceutical firms are
adopting digital tools to achieve modernisation. The biological phenomena within …
adopting digital tools to achieve modernisation. The biological phenomena within …
Opportunities and challenges of real‐time release testing in biopharmaceutical manufacturing
M Jiang, KA Severson, JC Love… - Biotechnology and …, 2017 - Wiley Online Library
Real‐time release testing (RTRT) is defined as “the ability to evaluate and ensure the quality
of in‐process and/or final drug product based on process data, which typically includes a …
of in‐process and/or final drug product based on process data, which typically includes a …
An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD
C Haringa - Engineering in Life Sciences, 2023 - Wiley Online Library
Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational
particles (parcels), provide information on environmental gradients inside bioreactors from …
particles (parcels), provide information on environmental gradients inside bioreactors from …