Senescence is defined as a gradual weakening of functional features of a living organism.
Cellular senescence is a process that is principally aimed to remove undesirable cells by …

Lung cancer is one of the most common malignant tumors in humans and the leading cause
of cancer-related deaths worldwide. The microRNA-34 (miR-34) family is dysregulated in …

Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with
DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been …

Background The occurrence in drug resistance of chronic myeloid leukemia (CML) was
accompanied by autophagy activation. Abnormal circular RNAs (circRNAs) participated in …

Low back pain is tightly associated with intervertebral disc degeneration (IVDD) and
aberrant nucleus pulposus (NP) is a critical cause. miRNAs N6-methyladenosine (m6A) …

How a cell determines a given phenotype upon damaged DNA is an open problem. Cell fate
decisions happen at cell cycle checkpoints and it is becoming clearer that the p53 pathway …

It is well established that microRNA-21 (miR-21) targets phosphatase and tensin homolog
(PTEN), facilitating epithelial-to-mesenchymal transition (EMT) and drug resistance in …

Patients with non-small cell lung cancer (NSCLC) are often treated with chemotherapy. Poor
clinical response and the onset of chemoresistance limit the anti-tumor benefits of drugs …

The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC).
In contrast, E2F1, an important transcription factor and tumor promoter, directly inhibits miR …

Long non-coding RNA (lncRNA) such as ANRIL and UFC1 have been verified as oncogenic
genes in non-small cell lung cancer (NSCLC). It is well known that the tumor suppressor …