Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Rho-GTPases are members of the Ras superfamily of small GTPases and are general
modulators of important cellular processes in tumor biology such as migration and …

Rationale: Extracellular matrix (ECM) remodeling, a key pathological feature in diabetic
cardiomyopathy (DCM), is triggered by oxidative stress, inflammation, and various metabolic …

Exosomes are secreted extracellular vesicles with lipid bilayer membranes. They are
emerging as a new category of messengers that facilitate cross-talk between cells, tissues …

Rationale: Atrial fibrillation (AF) is the most common arrhythmia, and advanced age is an
inevitable and predominant AF risk factor. However, the mechanisms that couple aging and …

Background: Inflammatory response after myocardial infarction (MI) is essential for cardiac
healing, whereas excessive and prolonged inflammation extends the infarction and …

Rnd3, also known as RhoE, belongs to the Rnd subclass of the Rho family of small GTP-
binding proteins. Rnd proteins are unique due to their inability to switch from a GTP-bound …

Rationale: Voltage-gated Na+ channel (I Na) function is critical for normal cardiac
excitability. However, the Na+ channel late component (I Na, L) is directly associated with …

RhoE/Rnd3 is an atypical member of the Rho superfamily of proteins, However, the global
biological function profile of this protein remains unsolved. In the present study, a RhoE …

Blood vessels are required for the survival of any organism larger than the oxygen diffusion
limit. Blood vessel formation is a tightly regulated event and vessel growth or changes in …