Co-evolution is a fundamental component of the theory of evolution and is essential for
understanding the relationships between species in complex ecological networks. A wide …

The physical interaction of proteins which lead to compiling them into large densely
connected networks is a noticeable subject to investigation. Protein interaction networks are …

Proteins do not function in isolation; it is their interactions with one another and also with
other molecules (eg DNA, RNA) that mediate metabolic and signaling pathways, cellular …

Protein–protein interactions (PPIs) are of vital importance to most biological processes.
Plenty of PPIs have been identified by wet-lab experiments in the past decades, but there …

Recent advances in high-throughput experimental methods for the identification of protein
interactions have resulted in a large amount of diverse data that are somewhat incomplete …

With many genomes now sequenced, computational annotation methods to characterize
genes and proteins from their sequence are increasingly important. The BioSapiens …

Recently a number of computational approaches have been developed for the prediction of
protein–protein interactions. Complete genome sequencing projects have provided the vast …

The genomic era has been characterised by vast amounts of data from diverse sources,
creating a need for new tools to extract biologically meaningful information. Bioinformatics is …

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …

DOMINE is a comprehensive collection of known and predicted domain–domain interactions
(DDIs) compiled from 15 different sources. The updated DOMINE includes 2285 new …