Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …

Significant advancements have been made in the application of chimeric antigen receptor
(CAR)-T treatment for blood cancers during the previous ten years. However, its …

The often immune-suppressive tumor microenvironment (TME) may hinder immune evasion
and response to checkpoint blockade therapies. Pharmacological activation of the STING …

The immunotherapy efficiency of stimulator of interferon genes (STING)-activatable drugs
(eg, 7-ethyl-10-hydroxycamptothecin, SN38) is limited by their non-specificity to tumor cells …

Immunotherapy represented by anti-PD-(L) 1 and anti-CTLA-4 inhibitors has revolutionized
cancer treatment, but challenges related to resistance and toxicity still remain. Due to the …

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor,
characterized by high heterogeneity, strong invasiveness, poor prognosis, and a low …

Macrophages play a pivotal role in tumor immunity. We report that reprogramming of
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …

cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated
immunomodulation. However, RT alone is insufficient to sustain STING activation in tumors …

Immunometabolism is a burgeoning field of research that investigates how immune cells
harness nutrients to drive their growth and functions. Myeloid cells play a pivotal role in …

T cells play a basic and key role in immunotherapy against solid tumors, and efficiently
recruiting them into neoplastic foci and sustaining long‐term effector function are consistent …