Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges

G Voiriot, M Oualha, A Pierre… - Annals of intensive …, 2022 - Springer
Background Post‐intensive care syndrome (PICS) encompasses physical, cognition, and
mental impairments persisting after intensive care unit (ICU) discharge. Ultimately it …

Mechanisms and treatment of organ failure in sepsis

C Lelubre, JL Vincent - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition

H Ma, X Zhang, L Liu, Y Huang, S Sun, K Chen… - Science …, 2023 - science.org
Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to
conflicts in free electron utilization, resulting in a lack of bioactivity of most near-infrared-II …

Pathophysiology of acute kidney injury

DP Basile, MD Anderson… - Comprehensive …, 2012 - pmc.ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Mechanisms of organ dysfunction in sepsis

R Pool, H Gomez, JA Kellum - Critical care clinics, 2018 - criticalcare.theclinics.com
Development of organ dysfunction is the most important clinical event during sepsis, as it
directly relates to mortality and morbidity. Although the new definition of sepsis captures this …

Distant organ dysfunction in acute kidney injury: a review

SA Lee, M Cozzi, EL Bush, H Rabb - American journal of kidney diseases, 2018 - Elsevier
Acute kidney injury (AKI) is common in critically ill patients and is associated with increased
morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes …

Pathophysiology of ischemic acute kidney injury

AA Sharfuddin, BA Molitoris - Nature Reviews Nephrology, 2011 - nature.com
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …

Immunopathophysiology of trauma-related acute kidney injury

DAC Messerer, R Halbgebauer, B Nilsson… - Nature Reviews …, 2021 - nature.com
Physical trauma can affect any individual and is globally accountable for more than one in
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …

Extracorporeal kidney-replacement therapy for acute kidney injury

S Gaudry, PM Palevsky… - New England Journal of …, 2022 - Mass Medical Soc
Extracorporeal Kidney-Replacement Therapy for AKI Acute kidney injury can be
accompanied by life-threatening electrolyte and metabolic abnormalities. Kidney …

Kidney-immune system crosstalk in AKI

K Singbartl, CL Formeck, JA Kellum - Seminars in nephrology, 2019 - Elsevier
Acute kidney injury (AKI) now is recognized as a systemic disease. It occurs frequently in
critically ill patients and has profound effects on morbidity and mortality. Recent research …