The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Circular RNAs in cancer: opportunities and challenges in the field

LS Kristensen, TB Hansen, MT Venø, J Kjems - Oncogene, 2018 - nature.com
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct
properties and diverse cellular functions, which is being explored at a steadily increasing …

CircRNAs: role in human diseases and potential use as biomarkers

L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

CircRNA: a novel type of biomarker for cancer

H Zhang, L Jiang, D Sun, J Hou, Z Ji - Breast cancer, 2018 - Springer
Circular RNAs (circRNAs) are a class of long, non-coding RNAs molecules that shape a
covalently closed continuous loop which have no 5′–3′ polarity and contain no polyA tail …

[HTML][HTML] An emerging function of circRNA-miRNAs-mRNA axis in human diseases

D Rong, H Sun, Z Li, S Liu, C Dong, K Fu, W Tang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs), a novel class of long noncoding RNAs, are characterized by a
covalently closed continuous loop without 5′ or 3′ polarities structure and have been …

Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression

Y Wu, Z **e, J Chen, J Chen, W Ni, Y Ma, K Huang… - Molecular cancer, 2019 - Springer
Background As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been
demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent …

circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis

JZ Xu, CC Shao, XJ Wang, X Zhao, JQ Chen… - Cell death & …, 2019 - nature.com
More and more evidence indicates that circular RNAs (circRNAs) have important roles in
several diseases, especially in cancers. However, their involvement remains to be …

Function and clinical significance of circRNAs in solid tumors

Y Geng, J Jiang, C Wu - Journal of hematology & oncology, 2018 - Springer
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA
regulates gene expression in many biological processes, and it also participates in the …

A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation

Q Yang, WW Du, N Wu, W Yang, FM Awan… - Cell Death & …, 2017 - nature.com
Circular RNAs (circRNAs) are a subclass of noncoding RNAs widely expressed in
mammalian cells. We report here the tumorigenic capacity of a circRNA derived from …