Synthesis of polyheterocyclic dimers containing restricted and constrained peptidomimetics via IMCR-based domino/double CuAAC click strategy

SG Pharande, MA Rentería-Gómez, R Gámez-Montaño - Molecules, 2020‏ - mdpi.com
A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem
was developed for the synthesis of restricted and constrained bis-1, 2, 3-triazole-linked …

[PDF][PDF] Peptides and peptidоmimetics in neuropharmacology

EN Encheva-Stoykova, DS Tsekova… - Journal of Chemical …, 2023‏ - j.uctm.edu
Peptides and peptidomimetics are a major field of bioorganic chemistry research. We
endeavored to describe the current trends in medicinal and bioorganic chemistry regarding …

[PDF][PDF] L-VALINE PEPTIDOMIMETIC EFFECT ON NEURAL FUNCTIONS.

EN Encheva-Stoykova, DS Tsekova… - Journal of Chemical …, 2020‏ - journal.uctm.edu
Peptidomimetics are a class of chemical compounds, many of which are being developed as
potential medications. Social isolation stress is known to negatively affect …

[PDF][PDF] The influence of solvents on the molecular structure and biological activity Of N, N/-Bis (N-nicotinoyl-l-valyl)-diaminohexane

DS Tsekova, R Klisurov, L Tancheva… - J. Chem. Technol …, 2013‏ - journal.uctm.edu
ABSTRACT A peptidomimetic, N, N/-bis (N-nicotinoyl-L-valyl)-diaminohexane (M6)
dissolved in identical concentration in three different types of solvent-sunflower oil, water …

[PDF][PDF] New L-valine peptide mimetics as potential neuropharmacological agents

LP Tancheva, EN Encheva, DS Tsekova, LG Alova… - BULGARIAN CHEMICAL …‏ - bcc.bas.bg
Aim of the present study was to evaluate the effect of four recently synthesized peptide
mimetics, derivatives of L-Valine, containing moieties of nicotinic/isonicotinic acids and …

[PDF][PDF] Microstructure of new metal-organic gels obtained by low-molecular gelators

DS Tsekova, VB Stoyanova - In Memoriam, 2009‏ - bcc.bas.bg
We have studied self-assembly properties of recently synthesized L-Valine and pyridine
containing low-molecular compounds, in the presence of some metal ions. It turned out that …

[CITATION][C] P. 1. g. 073 Modulation of 5-HT-Ach interactions in the hippocampus by newly synthesised peptidomimetics in an experimental model of aggression in rats

R Klisurov, E Encheva, L Tancheva, L Shikova… - European …, 2013‏ - Elsevier

[CITATION][C] P. 1. g. 074 Plasma concentrations of paroxetine among treatment responder inpatients at week one and before discharge

G Eryilmaz, ME Ceylan, BO Unsalver… - European …, 2013‏ - Elsevier