Dynamic modeling of how particulate matter (PM) transport, deposit, and translocate from
human respiratory systems to systemic regions subject to indoor and outdoor exposures are …

In silico mechanistic modeling approaches have been designed by various stakeholders
with the goal of supporting development and approval of generic orally inhaled drug …

Understanding nano-particle inhalation in human lung airways helps targeted drug delivery
for treating lung diseases. A wide range of numerical models have been developed to …

Most existing whole lung models neglect the airway deformation kinematics and assume the
lung airways are static. However, neglecting the airway deformation effect on pulmonary air …

Rationale: Dynamic collapse of the tracheal lumen (tracheomalacia) occurs frequently in
premature neonates, particularly in those with common comorbidities such as …

Documentation of comparability between generic inhaler designs and the reference listed
drug (RLD) inhalers is essential for regulatory approval of the products. Such assessments …

This study presents a novel coupled computational fluid dynamics-discrete element method
(CFD-DEM) model for simulating airflow and inhaled particle dynamics in the nasal cavity …

The flow characteristics and heat transfer during nasal breathing in the complete human
upper airway were investigated through the respiratory cycle using transient numerical …

Aerosol drug delivery in the human airway is significantly affected by the morphology and
size of the airway. This work developed a CFD-DEM model to simulate and analyze air flow …

To enhance understanding of the airflow characteristics in the human respiratory system
during realistic inspiration, we investigated the airflow field in a human upper airway model …