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Hallmarks of neurodegenerative diseases
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …
Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
L Qian, Y Zhu, C Deng, Z Liang, J Chen… - Signal transduction and …, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
Disruption of mitochondrial complex I induces progressive parkinsonism
Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the
substantia nigra is a hallmark of Parkinson's disease. Yet, whether this change contributes to …
substantia nigra is a hallmark of Parkinson's disease. Yet, whether this change contributes to …
Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology
TM Goralski, L Meyerdirk, L Breton, L Brasseur… - Nature …, 2024 - nature.com
A key hallmark of Parkinson's disease (PD) is Lewy pathology. Composed of α-synuclein,
Lewy pathology is found both in dopaminergic neurons that modulate motor function, and …
Lewy pathology is found both in dopaminergic neurons that modulate motor function, and …
Precision drug delivery to the central nervous system using engineered nanoparticles
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
Prodromal Parkinson disease subtypes—key to understanding heterogeneity
In Parkinson disease (PD), pathological processes and neurodegeneration begin long
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …
before the cardinal motor symptoms develop and enable clinical diagnosis. In this prodromal …
Inflammation in Parkinson's disease: mechanisms and therapeutic implications
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …