Phosphatidylcholine-derived lipid mediators: the crosstalk between cancer cells and immune cells

RF Saito, LNS Andrade, SO Bustos… - Frontiers in …, 2022 - frontiersin.org
To become resistant, cancer cells need to activate and maintain molecular defense
mechanisms that depend on an energy trade-off between resistance and essential functions …

Organic cation transporters in health and disease

H Koepsell - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Oral squamous cell carcinoma diagnosed from saliva metabolic profiling

X Song, X Yang, R Narayanan, V Shankar… - Proceedings of the …, 2020 - pnas.org
Saliva is a noninvasive biofluid that can contain metabolite signatures of oral squamous cell
carcinoma (OSCC). Conductive polymer spray ionization mass spectrometry (CPSI-MS) is …

Acetylcholine signaling system in progression of lung cancers

JR Friedman, SD Richbart, JC Merritt, KC Brown… - Pharmacology & …, 2019 - Elsevier
The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung
cancer. Several lines of evidence show that lung cancer cells express all of the proteins …

[HTML][HTML] Metabolomics: the stethoscope for the twenty-first century

H Ashrafian, V Sounderajah, R Glen, T Ebbels… - Medical Principles and …, 2021 - karger.com
Metabolomics encompasses the systematic identification and quantification of all metabolic
products in the human body. This field could provide clinicians with novel sets of diagnostic …

[HTML][HTML] Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer …

X Wang, J Zhang, K Zheng, Q Du, G Wang… - Journal of …, 2023 - Elsevier
Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted
therapy. However, metabolic inhibitors are limited by the drug resistance of cancerous cells …

Enzyme-based biosensors for choline analysis: A review

P Rahimi, Y Joseph - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Choline is an essential nutrient that is crucial for normal cellular function and its daily intake
is recommended by the US National Academy of Sciences. Choline and its derivatives play …

5-Hydroxymethylome in circulating cell-free DNA as a potential biomarker for non-small-cell lung cancer

J Zhang, X Han, C Gao, Y **ng, Z Qi… - Genomics …, 2018 - academic.oup.com
Non-small-cell lung cancer (NSCLC), the most common type of lung cancer accounting for
85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early …

Mechanisms of exacerbation of Th2-mediated eosinophilic allergic asthma induced by plastic pollution derivatives (PPD): A molecular toxicological study involving …

H Wei, S Lu, M Chen, R Yao, B Yan, Q Li… - Science of The Total …, 2024 - Elsevier
Polystyrene microplastics (PS-MP) and dibutyl phthalate (DBP) are plastic pollution
derivatives (PPDs) commonly found in the natural environment. To investigate the effects of …

Noninvasive prediction of TERT promoter mutations in high‐grade glioma by radiomics analysis based on multiparameter MRI

H Tian, H Wu, G Wu, G Xu - BioMed research international, 2020 - Wiley Online Library
Objectives. To investigate the predictors of telomerase reverse transcriptase (TERT)
promoter mutations in adults suffered from high‐grade glioma (HGG) through radiomics …