Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic
function during neurodegenerative disorders. We identified a specific apolipoprotein E …

Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD …

Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human
brain. The current consensus is that cerebral organoids consist of cells derived from the …

Aging brains undergo cognitive decline, associated with decreased neuronal synapse
number and function and altered metabolism. Astrocytes regulate neuronal synapse …

Neuroinflammation in the central nervous system (CNS) is an important subject of
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …