Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of
polyunsaturated phospholipids on cell membranes and is actively suppressed by the …

Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing
enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol …

Adrenal insufficiency continues to be a challenge for patients, their physicians, and
researchers. During the past decade, long-term studies have shown increased mortality and …

Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Cholesterol homeostasis is critical for normal growth and development. In addition to being
a major membrane lipid, cholesterol has multiple biological functions. These roles include …

Context: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the
exact origin of hyperandrogenemia remains a matter of debate. Recent studies have …

Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult humans
have provided convincing evidence of its thermogenic potential and role in clearing …