Challenges to liver transplantation and strategies to improve outcomes

P Dutkowski, M Linecker, ML DeOliveira, B Müllhaupt… - Gastroenterology, 2015 - Elsevier
Liver transplantation (LT) is a highly successful treatment for many patients with
nonmalignant and malignant liver diseases. However, there is a worldwide shortage of …

Machine perfusion of the liver: applications in transplantation and beyond

CDL Ceresa, D Nasralla, JM Pollok… - Nature reviews …, 2022 - nature.com
The shortage of donor livers considered suitable for transplantation has driven the
development of novel methods for organ preservation and reconditioning. Machine …

[HTML][HTML] Aktualisierte S2k-Leitlinie nicht-alkoholische Fettlebererkrankung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs-und …

E Roeb, A Canbay, H Bantel, J Bojunga… - Zeitschrift für …, 2022 - thieme-connect.com
Das Fortschreiten einer NASH ist assoziiert mit Leberzellstress, konsekutiver Entzündung
und Fibrose, mit potentieller Entwicklung einer Leberzirrhose, portaler Hypertension und der …

Transplantation of discarded livers following viability testing with normothermic machine perfusion

H Mergental, RW Laing, AJ Kirkham… - Nature …, 2020 - nature.com
There is a limited access to liver transplantation, however, many organs are discarded
based on subjective assessment only. Here we report the VITTAL clinical trial (ClinicalTrials …

EASL clinical practice guidelines: liver transplantation

European Association for The Study of the Liver - Journal of hepatology, 2016 - Elsevier
The first human orthotopic liver transplantation (LT) in Europe was performed by Sir Roy
Calne in Cambridge in 1968 [1], only one year after the first successful human liver …

First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched …

P Dutkowski, WG Polak, P Muiesan, A Schlegel… - Annals of …, 2015 - journals.lww.com
Background: Exposure of donor liver grafts to prolonged periods of warm ischemia before
procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft …

Defining benchmarks in liver transplantation: a multicenter outcome analysis determining best achievable results

X Muller, F Marcon, G Sapisochin, M Marquez… - Annals of …, 2018 - journals.lww.com
This multicentric study of 17 high-volume centers presents 12 benchmark values for liver
transplantation. Those values, mostly targeting markers of morbidity, were gathered from …

A multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation

A Schlegel, M van Reeven, K Croome, A Parente… - Journal of …, 2022 - Elsevier
Background & Aims The concept of benchmarking is established in the field of transplant
surgery; however, benchmark values for donation after circulatory death (DCD) liver …

The UK DCD Risk Score: a new proposal to define futility in donation-after-circulatory-death liver transplantation

A Schlegel, M Kalisvaart, I Scalera, RW Laing… - Journal of …, 2018 - Elsevier
Background & Aims Primary non-function and ischaemic cholangiopathy are the most feared
complications following donation-after-circulatory-death (DCD) liver transplantation. The aim …

Extended criteria donors in liver transplantation

I Vodkin, A Kuo - Clinics in liver disease, 2017 - liver.theclinics.com
Mortality rates on the liver transplant waiting list are increasing. 1 The shortage of organs
has resulted in higher utilization of extended criteria donors (ECDs), with centers pushing …