Pharmacological treatment of COVID-19: an opinion paper

A García-Lledó, J Gómez-Pavón… - Revista Española …, 2021 - pmc.ncbi.nlm.nih.gov
The precocity and efficacy of the vaccines developed so far against COVID-19 has been the
most significant and saving advance against the pandemic. The development of vaccines …

Remdesivir: a review in COVID-19

HA Blair - Drugs, 2023 - Springer
Remdesivir (Veklury®), a nucleotide analogue prodrug with broad-spectrum antiviral activity,
is approved for the treatment of coronavirus disease 2019 (COVID-19), the illness caused by …

Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis

R Beckerman, A Gori, S Jeyakumar, JJ Malin… - Scientific Reports, 2022 - nature.com
This network meta-analysis (NMA) assessed the efficacy of remdesivir in hospitalized
patients with COVID-19 requiring supplemental oxygen. Randomized controlled trials of …

The efficacy and safety of remdesivir alone and in combination with other drugs for the treatment of COVID-19: A systematic review and meta-analysis

C Chen, J Fang, S Chen, MJN Rajaofera, X Li… - BMC Infectious …, 2023 - Springer
Background Remdesivir is considered to be a specific drug for treating coronavirus disease
2019. This systematic review aims to evaluate the clinical efficacy and risk of remdesivir …

Survival benefit of remdesivir in hospitalized COVID-19 patients with high SARS-CoV-2 viral loads and low-grade systemic inflammation

S Padilla, K Polotskaya, M Fernández… - Journal of …, 2022 - academic.oup.com
Objectives To assess the benefits of remdesivir in hospitalized COVID-19 patients receiving
combined immunomodulatory therapy (CIT) with dexamethasone and tocilizumab. Methods …

Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19

K Hagman, M Hedenstierna, J Widaeus… - Journal of …, 2023 - academic.oup.com
Background Studies on the antiviral effects of remdesivir have shown conflicting results.
SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly …

Early use of remdesivir and risk of disease progression in hospitalized patients with mild to moderate COVID-19

M Falcone, LR Suardi, G Tiseo, C Barbieri, L Giusti… - Clinical Therapeutics, 2022 - Elsevier
Purpose Preliminary data suggest that remdesivir may influence the course of COVID-19
according to the duration of pre-admission symptoms. We aim to evaluate whether early use …

[HTML][HTML] Antiviral drugs against SARS-CoV-2

TF Aiello, C García-Vidal, A Soriano - Revista Española de …, 2022 - ncbi.nlm.nih.gov
The use of antiviral drugs represents an important progress in the therapeutic management
of COVID-19, leading to a substantial reduction of SARS-CoV-2-related complications and …

Current outcomes of SARS-CoV-2 Omicron variant infection in high-risk haematological patients treated early with antivirals

TF Aiello, P Puerta-Alcalde, M Chumbita… - Journal of …, 2023 - academic.oup.com
Objectives We aimed to describe the clinical outcomes and duration of viral shedding in high-
risk patients with haematological malignancies hospitalized with COVID-19 during Omicron …

Time from symptoms onset to remdesivir is associated with the risk of ICU admission: a multicentric analyses

R Alonso-Navarro, M Ramírez, M Masiá… - BMC infectious …, 2023 - Springer
Background Shorter duration of symptoms before remdesivir has been associated with
better outcomes. Our goal was to evaluate variables associated with the need of ICU …