Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity
Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …
the aid of experimental spectroscopic techniques reveals that this specific combination of …
Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine
OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …
biological properties and diverse therapeutic applications in medicinal research. They are …
A perspective on monoamine oxidase enzyme as drug target: challenges and opportunities
The monoamine oxidase (MAO) enzyme is responsible for the deamination of monoamine
neurotransmitters and regulates their concentration in the central and peripheral nervous …
neurotransmitters and regulates their concentration in the central and peripheral nervous …
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors
Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2)
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
Exploring new selective 3-benzylquinoxaline-based MAO-A inhibitors: design, synthesis, biological evaluation and docking studies
In this investigation, we searched for novel MAO-A inhibitors using a 3-benzylquinoxaline
scaffold based on our earlier findings. Series of N′-(3-benzylquinoxalin-2-yl) …
scaffold based on our earlier findings. Series of N′-(3-benzylquinoxalin-2-yl) …
Recent advances in the synthesis of biologically active cinnoline, phthalazine and quinoxaline derivatives
In the recent decades, N-heterocycles are widely used as versatile scaffolds for the
development of biologically active compounds and considered as one of the privileged …
development of biologically active compounds and considered as one of the privileged …
Design, synthesis and biological evaluation of novel 1, 2, 4-triazolo and 1, 2, 4-triazino [4, 3-a] quinoxalines as potential anticancer and antimicrobial agents
DAE Issa, NS Habib, AEA Wahab - MedChemComm, 2015 - pubs.rsc.org
In an effort to find new leads as anticancer or antimicrobial agents, the present work deals
with the synthesis of some novel 1-substituted 1, 2, 4-triazolo [4, 3-a] quinoxalines 7, 9a, b …
with the synthesis of some novel 1-substituted 1, 2, 4-triazolo [4, 3-a] quinoxalines 7, 9a, b …
Design, synthesis, and biological evaluation of novel MAO-A inhibitors targeting lung cancer
Lung cancer is one of the most common causes of cancer-related deaths worldwide.
Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen …
Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen …