Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Marine sponges often contain diverse and abundant microbial communities, including
bacteria, archaea, microalgae, and fungi. In some cases, these microbial associates …

In this review those fluorinated compounds which have found a role as anti-cancer agents
are summarized. The emphasis is to highlight the important drugs but also to highlight the …

A number of microtubule (MT)-stabilizing agents (MSAs) have demonstrated or predicted
potential as anticancer agents, but a detailed structural basis for their mechanism of action is …

The marine environment has proven to be a very rich source of extremely potent compounds
that have demonstrated significant activities in antitumor, antiinflammatory, analgesia …

Marine sponges have been considered as a drug treasure house with respect to great
potential regarding their secondary metabolites. Most of the studies have been conducted …

Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Marine sponges have been considered as a gold mine during the past 50 years, with
respect to the diversity of their secondary metabolites. The biological effects of new …

Despite the huge investment into research and the significant effort and advances made in
the search for new anticancer drugs in recent decades, cancer cure and treatment continue …