Synthesis, antimicrobial activity, molecular docking, molecular dynamics simulation, and ADMET properties of the mannopyranoside derivatives as antimicrobial …

AU Islam, H Hadni, F Ali, A Abuzreda… - Journal of Taibah …, 2024 - Taylor & Francis
Multiple diseases are treated with carbohydrate-based medicinal products worldwide. Direct
regioselective acylation of methyl α-D-mannopyranoside (MDMP) derivatives 2-6 afforded …

[HTML][HTML] The Synergistic Influence of Polyflavonoids from Citrus aurantifolia on Diabetes Treatment and Their Modulation of the PI3K/AKT/FOXO1 Signaling Pathways …

MA Hassan, GMA Elmageed, IG El-Qazaz… - Pharmaceutics, 2023 - mdpi.com
This study was aimed at probing the modulatory influence of polyflavonoids extracted from
Citrus aurantifolia, lemon peel extract (LPE-polyflavonoids), on attenuating diabetes mellitus …

Genotoxic effects and mitosis aberrations of chromium (VI) on root cells of Vicia faba and its molecular docking analysis

M Bouhadi, O Abchir, I Yamari, AEH El Youbi… - Plant physiology and …, 2024 - Elsevier
Like other heavy metals, Cr (VI) is a powerful carcinogen and mutagen agent. Its toxic effects
on plants are well considered. In order to elucidate its adverse effects, the present work aims …

Design, synthesis, in-vitro, in-silico and DFT studies of novel functionalized isoxazoles as antibacterial and antioxidant agents

A Arzine, O Abchir, M Chalkha, K Chebbac… - … Biology and Chemistry, 2024 - Elsevier
A series of new isoxazolederivatives incorporating the sulfonate ester function has been
synthesized from 2-benzylidenebenzofuran-3 (2 H)-one, known as aurone. The synthesis of …

Synthesis, characterization, mechanistic study, in-vitro and in-silico evaluation of antibacterial and antioxidant activities of novel pyrazole-pyrazoline hybrid systems

N Barghady, M Chalkha, I Yamari, N Aflak… - Journal of Molecular …, 2024 - Elsevier
This study describes the synthesis, characterization, and in vitro as well as in silico
assessment of the biological activity of a new series of hybrid molecules. These target …

[HTML][HTML] Exploring the therapeutic mechanism of potential phytocompounds from Kalanchoe pinnata in the treatment of diabetes mellitus by integrating network …

RY Halayal, ZK Bagewadi, NA Aldabaan… - Saudi Pharmaceutical …, 2024 - Elsevier
Since ancient times, bioactive phytocompounds from different parts of medicinal plants have
been used to heal various disease ailments and they are now regarded as a valuable …

[HTML][HTML] Ligand based-design of potential schistosomiasis inhibitors through QSAR, homology modeling, molecular dynamics, pharmacokinetics, and DFT studies

C Saudatu, A Uzairu, A Chandra, MS Sallau… - Journal of Taibah …, 2024 - Elsevier
Schistosomiasis, also known as bilharzia or snail fever, is a tropical disease caused by
parasitic flatworms belonging to the Schistosoma genus. This disease remains a prevalent …

Design, synthesis and anti-hyperglycemic assessments of novel 5-benzylidenethiazolidine-2, 4-dione derivatives as PPAR-γ agonist

A Ali, A Ali, V Asati, S Kaya, MJ Ahsan - Journal of the Indian Chemical …, 2023 - Elsevier
The treatment of diabetes mellitus still relies predominantly on peroxisome proliferator-
activated receptor-γ (PPAR-γ) therapy, known for its effectiveness. In this present study, a …

[HTML][HTML] Unveiling Moroccan Nature's Arsenal: A Computational Molecular Docking, Density Functional Theory, and Molecular Dynamics Study of Natural Compounds …

I Yamari, O Abchir, H Nour, M Khedraoui, B Rossafi… - Pharmaceuticals, 2024 - mdpi.com
Candida albicans and Aspergillus fumigatus are recognized as significant fungal pathogens,
responsible for various human infections. The rapid emergence of drug-resistant strains …

Phytochemical analysis, antimicrobial and antioxidant activities of essential oils of the species Artemisia mesatlantica maire: in vitro and in silico approaches

K Chebbac, O Abchir, M Chalkha… - CyTA-Journal of …, 2024 - Taylor & Francis
In the present work, we assessed the antioxidant, antibacterial, and antifungal activities of
chemically defined Artemisia mesatlantica Maire (EOAM) essential oils. The GC-MS analysis …