Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Male fertility throughout life hinges on the successful production of motile sperm, a
developmental process that involves three coordinated transitions: mitosis, meiosis, and …

Infertility is a common problem affecting one in six couples and in 30% of infertile couples,
the male factor is a major cause. A large number of genes are involved in spermatogenesis …

Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden
due to concomitant suppressor systems. Accordingly, we know little of their evolutionary …

BACKGROUND Studies in non-human mammals suggest that environmental factors can
influence spermatozoal DNA methylation, and some research suggests that spermatozoal …

Protamine is a natural cationic peptide mixture mostly known as a drug for the neutralization
of heparin and as a compound in formulations of slow-release insulin. Protamine is also …

Male germ cells undergo an extreme but fascinating process of chromatin remodeling that
begins in the testis during the last phase of spermatogenesis and continues through …

The spermatozoon is a highly differentiated cell with unique characteristics: it is mobile,
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …