Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

The immune response is initiated in organized lymphoid tissues where antigen-loaded
dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of …

Summary Lymphocyte-activation gene 3 (LAG-3) is an immune inhibitory receptor, with
major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains …

After a century of using the Bacillus Calmette–Guérin (BCG) vaccine, our understanding of
its ability to provide protection against homologous (Mycobacterium tuberculosis) or …

Trail+DX5 Eomes natural killer (NK) cells arise in the mouse fetal liver and persist in the
adult liver. Their relationships with Trail DX5+ NK cells remain controversial. We generated …

Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority
of the responding T cells has not been defined. To address this issue we used tetramers of …

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many
extracellular stimuli. Here we show that naive human T cells had very low expression of PLC …

It is known that T cells engage antigen-presenting cells (APCs) in a stable interaction that
results in sustained TCR signaling. We show here that the duration of this process is critical …

▪ Abstract Immunological memory can be defined as the faster and stronger response of an
animal that follows reexposure to the same antigen. By this definition, it is an operational …

In a depleted lymphoid compartment, naive T cells begin a slow proliferation that is
independent of cognate antigen yet requires recognition of major histocompatibility complex …