Artificial scaffolds in cardiac tissue engineering
Cardiovascular diseases are a leading cause of death worldwide. Current treatments
directed at heart repair have several disadvantages, such as a lack of donors for heart …
directed at heart repair have several disadvantages, such as a lack of donors for heart …
Differentiation and application of human pluripotent stem cells derived cardiovascular cells for treatment of heart diseases: Promises and challenges
Y Gao, J Pu - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Human pluripotent stem cells (hPSCs) are derived from human embryos (human embryonic
stem cells) or reprogrammed from human somatic cells (human induced pluripotent stem …
stem cells) or reprogrammed from human somatic cells (human induced pluripotent stem …
Human cardiac organoids for modeling genetic cardiomyopathy
M Filippo Buono, L von Boehmer, J Strang… - Cells, 2020 - mdpi.com
Genetic cardiomyopathies are characterized by changes in the function and structure of the
myocardium. The development of a novel in vitro model could help to better emulate healthy …
myocardium. The development of a novel in vitro model could help to better emulate healthy …
PPARγ and NOTCH Regulate Regional Identity in the Murine Cardiac Outflow Tract
M Rammah, M Théveniau-Ruissy, R Sturny… - Circulation …, 2022 - Am Heart Assoc
Background: The arterial pole of the heart is a hotspot for life-threatening forms of congenital
heart defects (CHDs). Development of this cardiac region occurs by addition of Second …
heart defects (CHDs). Development of this cardiac region occurs by addition of Second …
Human embryonic stem cell-derived cardiovascular progenitor cells efficiently colonize in bFGF-tethered natural matrix to construct contracting humanized rat hearts
Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived
cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to …
cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to …
Development and evolution of the metazoan heart
RE Poelmann… - Developmental …, 2019 - Wiley Online Library
The mechanisms of the evolution and development of the heart in metazoans are
highlighted, starting with the evolutionary origin of the contractile cell, supposedly the …
highlighted, starting with the evolutionary origin of the contractile cell, supposedly the …
Cardiomyogenesis modeling using pluripotent stem cells: the role of microenvironmental signaling
Pluripotent stem cells (PSC) can be used as a model to study cardiomyogenic differentiation.
In vitro modeling can reproduce cardiac development through modulation of some key …
In vitro modeling can reproduce cardiac development through modulation of some key …
The role of reactive oxygen species in in vitro cardiac maturation
Recent advances in developmental biology and biomedical engineering have significantly
improved the efficiency and purity of cardiomyocytes (CMs) generated from pluripotent stem …
improved the efficiency and purity of cardiomyocytes (CMs) generated from pluripotent stem …
Expansion of human pluripotent stem cell-derived early cardiovascular progenitor cells by a cocktail of signaling factors
Cardiovascular progenitor cells (CPCs) derived from human pluripotent stem cells (hPSCs)
are proposed to be invaluable cell sources for experimental and clinical studies. This wide …
are proposed to be invaluable cell sources for experimental and clinical studies. This wide …
Cardiomyogenic differentiation is fine-tuned by differential mRNA association with polysomes
Background Cardiac cell fate specification occurs through progressive steps, and its gene
expression regulation features are still being defined. There has been an increasing interest …
expression regulation features are still being defined. There has been an increasing interest …