Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Macropinocytic cancer cells scavenge amino acids from extracellular proteins. Here, we
show that consuming necrotic cell debris via macropinocytosis (necrocytosis) offers …

Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma
membrane. These close to entrap droplets of medium into micron-sized vesicles, which are …

Endocytosis mechanisms are one of the methods that cells use to interact with their
environments. Endocytosis mechanisms vary from the clathrin-mediated endocytosis to the …

Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a
highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and …

Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …

The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer …

Iron oxide nanoparticles (IONs) have been widely explored for biomedical applications due
to their high biocompatibility, surface-coating versatility, and superparamagnetic properties …

Endocytosis is a fundamental mechanism by which cells perform housekee** functions. It
occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase …