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Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars
GC Limandjaja, FB Niessen… - Experimental …, 2021 - Wiley Online Library
Although hypertrophic scars and keloids both generate excessive scar tissue, keloids are
characterized by their extensive growth beyond the borders of the original wound, which is …
characterized by their extensive growth beyond the borders of the original wound, which is …
Keloid disorder: fibroblast differentiation and gene expression profile in fibrotic skin diseases
EJ Macarak, PJ Wermuth… - Experimental …, 2021 - Wiley Online Library
Keloid disorder, a group of fibroproliferative skin diseases, is characterized by unremitting
accumulation of the extracellular matrix (ECM) of connective tissue, primarily collagen, to …
accumulation of the extracellular matrix (ECM) of connective tissue, primarily collagen, to …
[HTML][HTML] Integrated analysis of single-cell and spatial transcriptomics in keloids: highlights on fibrovascular interactions in keloid pathogenesis
Studies on the etiopathogenesis of keloids mostly have focused on fibroblasts and their
dysfunction. In this study, two cutting-edge technologies, single-cell RNA sequencing and …
dysfunction. In this study, two cutting-edge technologies, single-cell RNA sequencing and …
[HTML][HTML] The role of AKR1B10 in physiology and pathophysiology
S Endo, T Matsunaga, T Nishinaka - Metabolites, 2021 - mdpi.com
AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent
reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the …
reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the …
The role of macrophages in the formation of hypertrophic scars and keloids
Numerous studies have shown that macrophages can orchestrate the microenvironment
from the early stage of wound healing to the later stages of scar formation. However, few …
from the early stage of wound healing to the later stages of scar formation. However, few …
[HTML][HTML] Mechanomodulatory biomaterials prospects in scar prevention and treatment
Scarring is a major clinical issue that affects a considerable number of patients. The
associated problems go beyond the loss of skin functionality, as scars bring aesthetic …
associated problems go beyond the loss of skin functionality, as scars bring aesthetic …
RNA sequencing keloid transcriptome associates keloids with Th2, Th1, Th17/Th22, and JAK3-skewing
Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear,
inhibiting therapeutic development. Available treatment options have limited efficacy and …
inhibiting therapeutic development. Available treatment options have limited efficacy and …
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway
Z Xu, M Zhang, Y Wang, R Chen, S Xu, X Sun… - Frontiers in …, 2022 - frontiersin.org
Renal tubulointerstitial fibrosis (TIF), characterized by epithelial-to-mesenchymal transition
(EMT) of renal tubular epithelial cells, is the typical pathological alteration in diabetic …
(EMT) of renal tubular epithelial cells, is the typical pathological alteration in diabetic …
[PDF][PDF] Keloid lesions show increased IL-4/IL-13 signaling and respond to Th2-targeting dupilumab therapy
Keloids are benign growths representing a disrupted wound healing process involving
abnormal collagen proliferation. Keloids are most prevalent in African American (AA) 1 and …
abnormal collagen proliferation. Keloids are most prevalent in African American (AA) 1 and …
Mast cells in skin scarring: a review of animal and human research
S Ud-Din, TA Wilgus, A Bayat - Frontiers in immunology, 2020 - frontiersin.org
Mast cells (MCs) are an important immune cell type in the skin and play an active role during
wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re …
wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re …