Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is
the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the …

The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized
by excessive deposition of extracellular matrix proteins, is the common pathway leading to …

Abstract Background: Extracellular vesicles (EVs) derived from plants have emerged as
potential candidates for cosmetic and therapeutic applications. In this study, we isolated EVs …

Wound healing requires a fine balance between the positive and deleterious effects of
reactive oxygen species (ROS); a group of extremely potent molecules, rate limiting in …

Chronic liver disease (CLD) affects a significant portion of the global population, leading to a
substantial number of deaths each year. Distinct forms like non-alcoholic fatty liver disease …

Hepatic fibrosis is a chronic liver disease that lacks effective pharmacotherapeutic
treatments. As part of the disease's mechanism, hepatic stellate cells (HSCs) are activated …

Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate
oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that …

Liver fibrosis is the pathological consequence of chronic liver diseases, where an excessive
deposition of extracellular matrix (ECM) proteins occurs, concomitantly with the processes of …