Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a
key transcription factor in the cellular defense against oxidative stress, playing a crucial role …

Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …

Lysosomes are best known for their roles in inflammatory responses by engaging in
autophagy to remove inflammasomes. Here, we describe an unrecognized role for the …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

The SARS-CoV-2 pandemic has had an unprecedented impact on global public health and
the economy. Although vaccines and antivirals have provided effective protection and …

Anaplastic thyroid cancer (ATC) is among the most aggressive and metastatic malignancies,
often resulting in fatal outcomes due to the lack of effective treatments. Prosapogenin A (PA) …

A cell death pathway, ferroptosis, occurs in conidial cells and is critical for formation and
function of the infection structure, the appressorium, in the rice blast fungus Magnaporthe …

Necroptosis and ferroptosis are two distinct forms of necrotic-like cell death in terms of their
morphological features and regulatory mechanisms. These two types of cell death can …

Autophagy is a lysosome‐mediated self‐degradation process of central importance for
cellular quality control. It also provides macromolecule building blocks and substrates for …