Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …

Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …

The breakthrough of reprogramming human somatic cells was achieved in 2006 by the work
of Yamanaka and Takahashi. From this point, fibroblasts are the most commonly used …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-
β) family that signal via type I and type II serine/threonine kinase receptors and intracellular …

Neural progenitor cells (NPCs) can be induced from somatic cells by defined factors. Here
we report that NPCs can be generated from mouse embryonic fibroblasts by a chemical …

Cellular reprogramming using chemically defined conditions, without genetic manipulation,
is a promising approach for generating clinically relevant cell types for regenerative …

Objective. Low back pain (LBP) is one of the top three causes of disability in developed
countries, and intervertebral disc degeneration (IDD) is a major contributor to LBP. In the …