Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
The widely used antimalarial combination therapy dihydroartemisinin+ piperaquine (DHA+
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …
Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in …
In Tanzania, chloroquine was replaced by sulphadoxine-pyrimethamine (SP) as a first-line
for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP …
for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP …
The natural function of the malaria parasite's chloroquine resistance transporter
The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor
to multidrug resistance and is also essential for the survival of the malaria parasite, yet its …
to multidrug resistance and is also essential for the survival of the malaria parasite, yet its …
Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria
Malaria caused by Plasmodium falciparum remains the leading single-agent cause of
mortality in children, yet the promise of an effective vaccine has not been fulfilled. Here …
mortality in children, yet the promise of an effective vaccine has not been fulfilled. Here …
Drug resistance in eukaryotic microorganisms
Eukaryotic microbial pathogens are major contributors to illness and death globally.
Although much of their impact can be controlled by drug therapy as with prokaryotic …
Although much of their impact can be controlled by drug therapy as with prokaryotic …
[HTML][HTML] The molecular basis of antimalarial drug resistance in Plasmodium vivax
Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …
responsible for the majority of cases outside of the African continent. While great progress …
Chloroquine and sulfadoxine–pyrimethamine resistance in Sub-Saharan Africa—A review
Malaria is a great concern for global health and accounts for a large amount of morbidity and
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …
Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum
J Schalkwijk, EL Allman, PAM Jansen… - Science translational …, 2019 - science.org
Malaria eradication is critically dependent on new therapeutics that target resistant
Plasmodium parasites and block transmission of the disease. Here, we report that …
Plasmodium parasites and block transmission of the disease. Here, we report that …