Targeting cancer vulnerabilities with high-dose vitamin C
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
Phosphonate biochemistry
Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …
A computational framework to explore large-scale biosynthetic diversity
Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …
initially performed on a single-genome basis, the process is now being scaled up to mine …
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Variants in the FTO (fat mass and obesity associated) gene are associated with increased
body mass index in humans. Here, we show by bioinformatics analysis that FTO shares …
body mass index in humans. Here, we show by bioinformatics analysis that FTO shares …
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
Abstract In contrast to 5-methylcytosine (5-mC), which has been studied extensively,,, little is
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …
known about 5-hydroxymethylcytosine (5-hmC), a recently identified epigenetic modification …
Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Recent studies have shown that lysines can be posttranslationally modified by various types
of acylations. However, except for acetylation, very little is known about their scope and …
of acylations. However, except for acetylation, very little is known about their scope and …
What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
JA Losman, WG Kaelin - Genes & development, 2013 - genesdev.cshlp.org
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …
Non-heme Fe (IV)–oxo intermediates
High-valent non-heme iron–oxo intermediates have been proposed for decades as the key
intermediates in numerous biological oxidation reactions. In the past three years, the first …
intermediates in numerous biological oxidation reactions. In the past three years, the first …
Quantum chemical studies of mechanisms for metalloenzymes
Two decades ago, theoretical model calculations played a truly minor role in understanding
mechanisms of redox-active metalloenzymes. The methods available to treat transition …
mechanisms of redox-active metalloenzymes. The methods available to treat transition …