[HTML][HTML] The impact of VEGF on cancer metastasis and systemic disease
Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …
Brain microvascular pericytes in vascular cognitive impairment and dementia
Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
Adventitial stromal cells define group 2 innate lymphoid cell tissue niches
MW Dahlgren, SW Jones, KM Cautivo, A Dubinin… - immunity, 2019 - cell.com
Type 2 lymphocytes promote both physiologic tissue remodeling and allergic pathology, yet
their physical tissue niches are poorly described. Here, we used quantitative imaging to …
their physical tissue niches are poorly described. Here, we used quantitative imaging to …
Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance
The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …
detached from the colony to enter into blood cells for obtaining a new place for metastasis …
Brain pericytes as mediators of neuroinflammation
Brain pericytes are perivascular cells that regulate capillary function, and this localization
puts them in a pivotal position for the regulation of central nervous system (CNS) …
puts them in a pivotal position for the regulation of central nervous system (CNS) …
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and
lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined …
lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined …
Novel strategies for cancer immunotherapy: counter-immunoediting therapy
S Liu, Q Sun, X Ren - Journal of Hematology & Oncology, 2023 - Springer
The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …
especially the application of immune checkpoint inhibitors in clinical practice. Although …
Targeting pericytes for therapeutic approaches to neurological disorders
J Cheng, N Korte, R Nortley, H Sethi, Y Tang… - Acta …, 2018 - Springer
Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …
associated with defects in microvascular function, including a failure to match the energy …
RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF‐κB pathway in oral squamous cell carcinoma
H Dan, S Liu, J Liu, D Liu, F Yin, Z Wei… - Molecular …, 2020 - Wiley Online Library
Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell
carcinoma (OSCC) progression, and RACK1 expression levels have been negatively …
carcinoma (OSCC) progression, and RACK1 expression levels have been negatively …
Fibroblast-derived IL33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type 2 immunity
O Shani, T Vorobyov, L Monteran, D Lavie, N Cohen… - Cancer research, 2020 - AACR
Lungs are one of the main sites of breast cancer metastasis. The metastatic
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …