Microtubules: From understanding their dynamics to using them as potential therapeutic targets

Y Ilan - Journal of cellular physiology, 2019 - Wiley Online Library
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

Hepatitis B virus capsid: the core in productive entry and covalently closed circular DNA formation

MA Mendenhall, X Hong, J Hu - Viruses, 2023 - mdpi.com
Hepatitis B virus (HBV) relies on the core protein (HBc) to establish productive infection, as
defined by the formation of the covalently closed circularized DNA (cccDNA), as well as to …

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

M Iwamoto, W Saso, R Sugiyama… - Proceedings of the …, 2019 - National Acad Sciences
Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for
hepatitis B virus (HBV) entry. However, the susceptibility of NTCP-expressing cells to HBV is …

The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network

M Iwamoto, W Saso, K Nishioka, H Ohashi… - Journal of Biological …, 2020 - ASBMB
Sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the surface of
human hepatocytes and functions as an entry receptor of hepatitis B virus (HBV). Recently …

Host functions used by hepatitis B virus to complete its life cycle: Implications for develo** host-targeting agents to treat chronic hepatitis B

B Mitra, RJ Thapa, H Guo, TM Block - Antiviral research, 2018 - Elsevier
Similar to other mammalian viruses, the life cycle of hepatitis B virus (HBV) is heavily
dependent upon and regulated by cellular (host) functions. These cellular functions can be …

[HTML][HTML] Viral capsid trafficking along treadmilling tubulin filaments in bacteria

V Chaikeeratisak, K Khanna, KT Nguyen, J Sugie… - Cell, 2019 - cell.com
Cargo trafficking along microtubules is exploited by eukaryotic viruses, but no such
examples have been reported in bacteria. Several large Pseudomonas phages assemble a …

Structural basis for hepatitis B virus restriction by a viral receptor homologue

K Shionoya, JH Park, T Ekimoto, JS Takeuchi… - Nature …, 2024 - nature.com
Macaque restricts hepatitis B virus (HBV) infection because its receptor homologue, NTCP
(mNTCP), cannot bind preS1 on viral surface. To reveal how mNTCP loses the viral receptor …

PIN1 and PIN4 inhibition via parvulin impeders Juglone, PiB, ATRA, 6,7,4′-THIF, KPT6566, and EGCG thwarted hepatitis B virus replication

U Saeed, ZZ Piracha - Frontiers in Microbiology, 2023 - frontiersin.org
Introduction Human parvulin peptidyl prolyl cis/trans isomerases PIN1 and PIN4 play
important roles in cell cycle progression, DNA binding, protein folding and chromatin …

Advances in HBV infection and replication systems in vitro

R Xu, P Hu, Y Li, A Tian, J Li, C Zhu - Virology Journal, 2021 - Springer
Abstract Background Hepatitis B virus (HBV) is a DNA virus belonging to the
Hepadnaviridae family that has limited tissue and species specificity. Due to the persistence …

Multiple mechanisms drive phage infection efficiency in nearly identical hosts

C Howard-Varona, KR Hargreaves… - The ISME …, 2018 - academic.oup.com
Phage–host interactions are critical to ecology, evolution, and biotechnology. Central to
those is infection efficiency, which remains poorly understood, particularly in nature. Here …