Deep brain stimulation: current challenges and future directions
The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …
Mechanisms of deep brain stimulation
TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …
Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease
Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …
brain disorders, but have so far been limited to short recordings from externalized brain …
Adaptive deep brain stimulation for Parkinson's disease using motor cortex sensing
NC Swann, C De Hemptinne… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Contemporary deep brain stimulation (DBS) for Parkinson's disease is delivered
continuously, and adjustments based on patient's changing symptoms must be made …
continuously, and adjustments based on patient's changing symptoms must be made …
Beta oscillations in working memory, executive control of movement and thought, and sensorimotor function
Beta oscillations (∼ 13 to 30 Hz) have been observed during many perceptual, cognitive,
and motor processes in a plethora of brain recording studies. Although the function of beta …
and motor processes in a plethora of brain recording studies. Although the function of beta …
Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …
Scaling brain size, kee** timing: evolutionary preservation of brain rhythms
Despite the several-thousand-fold increase of brain volume during the course of mammalian
evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for …
evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for …
Cross-frequency coupling and intelligent neuromodulation
Cross-frequency coupling (CFC) reflects (nonlinear) interactions between signals of different
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …
Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease
C De Hemptinne, NC Swann, JL Ostrem… - Nature …, 2015 - nature.com
Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but
its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS …
its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS …