Protein disulfide isomerase in cardiovascular disease

B **ong, V Jha, JK Min, J Cho - Experimental & molecular medicine, 2020 - nature.com
Protein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases.
Increasing evidence indicates that intravascular cell-derived PDI plays an important role in …

Roles of protein disulfide isomerase in breast cancer

S Yang, C Jackson, E Karapetyan, P Dutta, D Kermah… - Cancers, 2022 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of
breast cancer and has a poor prognosis and higher recurrence rate due to ineffective …

[HTML][HTML] Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes

S Xu, Y Liu, K Yang, H Wang, A Shergalis, A Kyani… - Theranostics, 2019 - ncbi.nlm.nih.gov
Aberrant overexpression of endoplasmic reticulum (ER)-resident oxidoreductase protein
disulfide isomerase (PDI) plays an important role in cancer progression. In this study, we …

ERO1-PDI redox signaling in health and disease

V Jha, T Kumari, V Manickam, Z Assar… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductase 1
(ERO1) are crucial for oxidative protein folding in the endoplasmic reticulum (ER). These …

Thiol isomerases orchestrate thrombosis and hemostasis

RS Gaspar, JM Gibbins - Antioxidants & Redox Signaling, 2021 - liebertpub.com
Significance: Since protein disulfide isomerase (PDI) was first described in 1963,
researchers have shown conclusively that PDI and sibling proteins are quintessential for …

Bacitracin and rutin regulate tissue factor production in inflammatory monocytes and acute myeloid leukemia blasts

L Beckmann, CC Rolling, M Voigtländer, J Mäder… - Cancers, 2021 - mdpi.com
Simple Summary Aberrant tissue factor (TF) expression by transformed myeloblasts and
inflammatory monocytes contributes to coagulation activation in acute myeloid leukemia …

Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence

H Xu, Y Wang, J Zhao, PW Jurutka… - Chemical Biology & …, 2020 - Wiley Online Library
Poria cocos is an edible and medicinal fungus that is widely used in Traditional Chinese
Medicines as well as in modern applications. Retinoid X receptor (RXR) occupies a central …

[HTML][HTML] Targeting a major hub of cell fate decisions–the mitochondrial-associated membrane

WL Carroll, NA Evensen - haematologica, 2019 - ncbi.nlm.nih.gov
3. Erikson GA, Bodian DL, Rueda M, et al. Whole-genome sequencing of a healthy aging
cohort. Cell. 2016; 165 (4): 1002-1011. 4. Wouters H, van der Klauw MM, de Witte T, et al …

[PDF][PDF] Roles of Protein Disulfide Isomerase in Breast Cancer. Cancers 2022, 14, 745

S Yang, C Jackson, E Karapetyan, P Dutta, D Kermah… - 2022 - academia.edu
Protein disulfide isomerase (PDI) is the endoplasmic reticulum (ER)'s most abundant and
essential enzyme and serves as the primary catalyst for protein folding. Due to its apparent …

[PDF][PDF] Construction and analysis of the protein interaction network between myeloid and lymphoid leukemia types

ON Hamad - 2022 - eprints.utm.my
In the last two decades, the study of interrelated cellular processes and biological pathways
has resulted in the discovery of novel disease-related genes or proteins; this effort has relied …