Subchondral bone microenvironment in osteoarthritis and pain

Y Hu, X Chen, S Wang, Y **g, J Su - Bone research, 2021 - nature.com
Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

I Bernabei, A So, N Busso, S Nasi - Nature Reviews Rheumatology, 2023 - nature.com
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis

D McGonagle, TG Baboolal, E Jones - Nature Reviews Rheumatology, 2017 - nature.com
The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in
the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone …

[HTML][HTML] Peripheral pain mechanisms in osteoarthritis

TL Vincent - Pain, 2020 - journals.lww.com
There is a well-established historical observation that structural joint damage by plain X-ray
correlates poorly with symptomatic disease in osteoarthritis (OA). This is often attributed to …

New trends in pharmacological treatments for osteoarthritis

X Cai, S Yuan, Y Zeng, C Wang, N Yu… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with
significant burden on the individual and society. It is a severe disease for its high disability …

[HTML][HTML] Mettl3 regulates osteogenic differentiation and alternative splicing of Vegfa in bone marrow mesenchymal stem cells

C Tian, Y Huang, Q Li, Z Feng, Q Xu - International Journal of Molecular …, 2019 - mdpi.com
Bone mesenchymal stem cells (BMSCs) can be a useful cell resource for develo**
biological treatment strategies for bone repair and regeneration, and their therapeutic …

Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis: a systematic review

P Dainese, H Mahieu, S De Mits, R Wittoek… - RMD open, 2023 - rmdopen.bmj.com
To provide an extensive review on the associations between knee inflammation and altered
pain perception mechanisms in people with knee osteoarthritis (OA). MEDLINE, Web of …

[HTML][HTML] Osteoarthritis bone marrow lesions

DA Walsh, N Sofat, A Guermazi, DJ Hunter - Osteoarthritis and cartilage, 2023 - Elsevier
Assessment and treatment of Bone Marrow Lesions (BMLs) could ultimately make step
changes to the lives of people with osteoarthritis (OA). We here review the imaging and …

[HTML][HTML] Best evidence rehabilitation for chronic pain part 5: osteoarthritis

D Rice, P McNair, E Huysmans, J Letzen… - Journal of clinical …, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which
most commonly affects the joints of the knee, hip, and hand. To date, there are no …

Osteoclasts and osteoarthritis: novel intervention targets and therapeutic potentials during aging

H Wang, T Yuan, Y Wang, C Liu, D Li, Z Li, S Sun - Aging Cell, 2024 - Wiley Online Library
Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …