Advances in the pathogenesis of psoriasis: from keratinocyte perspective

X Zhou, Y Chen, L Cui, Y Shi, C Guo - Cell death & disease, 2022 - nature.com
Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and
associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration …

Pathogenesis, multi-omics research, and clinical treatment of psoriasis

J Yu, Q Zhao, X Wang, H Zhou, J Hu, L Gu, Y Hu… - Journal of …, 2022 - Elsevier
Psoriasis is a common inflammatory skin disease involving interactions between
keratinocytes and immune cells that significantly affects the quality of life. It is characterized …

Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

[HTML][HTML] Epithelia-sensory neuron cross talk underlies cholestatic itch induced by lysophosphatidylcholine

Y Chen, ZL Wang, M Yeo, QJ Zhang… - Gastroenterology, 2021 - Elsevier
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver
diseases hinders development of antipruritic treatments. Previous studies implicated …

The sponge microbiome project

L Moitinho-Silva, S Nielsen, A Amir, A Gonzalez… - …, 2017 - academic.oup.com
Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in
southwest China covers several different habitats and environments. However, not much …

Updated perspectives on keratinocytes and psoriasis: keratinocytes are more than innocent bystanders

LI Ortiz-Lopez, V Choudhary… - Psoriasis: Targets and …, 2022 - Taylor & Francis
Psoriasis is a complex disease triggered by genetic, immunologic, and environmental
stimuli. Many genes have been linked to psoriasis, like the psoriasis susceptibility genes …

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

Y Li, G Hou, H Zhou, Y Wang, HM Tun, A Zhu… - Signal transduction and …, 2021 - nature.com
Disease progression prediction and therapeutic drug target discovery for Coronavirus
disease 2019 (COVID-19) are particularly important, as there is still no effective strategy for …

Metabolomics meets systems immunology

J Fu, F Zhu, CJ Xu, Y Li - EMBO reports, 2023 - embopress.org
Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

Aberrations in lipid expression and metabolism in psoriasis

J Nowowiejska, A Baran, I Flisiak - International journal of molecular …, 2021 - mdpi.com
Psoriasis (PSO) is a common skin disease that affects about 1%–3% of the general
population. It is a great medical, social and economic burden since PSO is associated with …

Psoriasis: Interplay between dysbiosis and host immune system

B Kapoor, M Gulati, P Rani, R Gupta - Autoimmunity reviews, 2022 - Elsevier
With advancement in human microbiome research, an increasing number of scientific
evidences have endorsed the key role of both gut and skin microbiota in the pathogenesis of …