An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

The AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that
regulates cellular and whole‐body energy balance. A recently reported crystal structure has …

KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously
reported that STK11/LKB1 (KL) or TP53 (KP) comutations define distinct subgroups of KRAS …

Intermediary metabolism generates substrates for chromatin modification, enabling the
potential coupling of metabolic and epigenetic states. Here we identify a network linking …

Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe
a luciferase knockin mouse (p16 LUC), which faithfully reports expression of p16 INK4a, a …

The identification of a complex containing the tumor suppressor LKB1 as the critical
upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by …

Abstract NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in
melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the …

This review aims to summarize the current knowledge of molecular pathways and their
clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent …

Since epidemiologic data have highlighted the positive effects of metformin to reduce cancer
incidence and mortality, many in vitro and in vivo studies as well as a large number of …

Metastasis is the leading cause of morbidity for lung cancer patients. Here we demonstrate
that murine tumor propagating cells (TPC s) with the markers S ca1 and CD 24 are enriched …