Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Behavioral methods to study anxiety in rodents
Stress is a precipitating factor for anxiety-related disorders, which are among the leading
forms of psychiatric illness and impairment in the modern world. Rodent-based behavioral …
forms of psychiatric illness and impairment in the modern world. Rodent-based behavioral …
The role of the opioid system in decision making and cognitive control: A review
The opioid system regulates affective processing, including pain, pleasure, and reward.
Restricting the role of this system to hedonic modulation may be an underestimation …
Restricting the role of this system to hedonic modulation may be an underestimation …
Kappa‐opioid antagonists for psychiatric disorders: From bench to clinical trials
WA Carlezon Jr, AD Krystal - Depression and anxiety, 2016 - Wiley Online Library
Kappa‐opioid receptor (KOR) antagonists are currently being considered for the treatment of
a variety of neuropsychiatric conditions, including depressive, anxiety, and substance abuse …
a variety of neuropsychiatric conditions, including depressive, anxiety, and substance abuse …
Kappa opioid receptor antagonists as potential therapeutics for stress-related disorders
Exposure to stressful stimuli activates kappa opioid receptor (KOR) signaling, a process
known to produce aversion and dysphoria in humans and other species. This endogenous …
known to produce aversion and dysphoria in humans and other species. This endogenous …
The potential role of learning capacity in cognitive behavior therapy for depression: A systematic review of the evidence and future directions for improving therapeutic …
SJE Bruijniks, RJ DeRubeis… - Clinical …, 2019 - journals.sagepub.com
Insight into how cognitive behavioral therapy (CBT) works is urgently needed to improve
depressive outcome. First, we discuss the role of learning in CBT for depression by …
depressive outcome. First, we discuss the role of learning in CBT for depression by …
Neural and behavioral markers of inhibitory control predict symptom improvement during internet-delivered cognitive behavioral therapy for depression
Poor inhibitory control contributes to deficits in emotion regulation, which are often targeted
by treatments for major depressive disorder (MDD), including cognitive behavioral therapy …
by treatments for major depressive disorder (MDD), including cognitive behavioral therapy …
Perturbations in effort-related decision-making driven by acute stress and corticotropin-releasing factor
Acute stress activates numerous systems in a coordinated effort to promote homeostasis,
and can exert differential effects on mnemonic and cognitive functions depending on a …
and can exert differential effects on mnemonic and cognitive functions depending on a …
The burden of brooding on neural error processing: The role of repetitive negative thinking in major depressive disorder with and without comorbid anxiety disorders
Background Repetitive negative thinking (RNT), particularly its brooding aspect, is a
prominent feature in Major Depressive Disorder (MDD) with and without comorbid anxiety …
prominent feature in Major Depressive Disorder (MDD) with and without comorbid anxiety …
Reinforcement learning deficits exhibited by postnatal PCP-treated rats enable deep neural network classification
The ability to appropriately update the value of a given action is a critical component of
flexible decision making. Several psychiatric disorders, including schizophrenia, are …
flexible decision making. Several psychiatric disorders, including schizophrenia, are …