Astrocytes: biology and pathology
Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They
contiguously tile the entire central nervous system (CNS) and exert many essential complex …
contiguously tile the entire central nervous system (CNS) and exert many essential complex …
Functional anatomy of T cell activation and synapse formation
T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …
B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
YR Carrasco, FD Batista - Immunity, 2007 - cell.com
Adaptive B cell responses are initiated by B cell receptor–antigen engagement. Despite its
importance, the early stages of B cell interaction with antigen in vivo remain elusive. Using …
importance, the early stages of B cell interaction with antigen in vivo remain elusive. Using …
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria
We report that two classes of membrane nanotubes between human monocyte-derived
macrophages can be distinguished by their cytoskeletal structure and their functional …
macrophages can be distinguished by their cytoskeletal structure and their functional …
[HTML][HTML] The role of antigen presenting cells in multiple sclerosis
EML Chastain, SD d'Anne, JM Rodgers… - Biochimica et Biophysica …, 2011 - Elsevier
Multiple sclerosis (MS) is a debilitating T cell mediated autoimmune disease of the central
nervous system (CNS). Animal models of MS, such as experimental autoimmune …
nervous system (CNS). Animal models of MS, such as experimental autoimmune …
Astrocytes in multiple sclerosis: a product of their environment
A Nair, TJ Frederick, SD Miller - Cellular and molecular life sciences, 2008 - Springer
It has long been thought that astrocytes, like other glial cells, simply provide a support
mechanism for neuronal function in the healthy and inflamed central nervous system (CNS) …
mechanism for neuronal function in the healthy and inflamed central nervous system (CNS) …
Cytotoxic immunological synapses
One of the most fundamental activities of the adaptive immune system is to kill infected cells
and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by …
and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by …
Understanding the structure and function of the immunological synapse
ML Dustin, AK Chakraborty… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The immunological synapse has been an area of very active scientific interest over the last
decade. Surprisingly, much about the synapse remains unknown or is controversial. Here …
decade. Surprisingly, much about the synapse remains unknown or is controversial. Here …
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
To through light on the mechanisms underlying the stimulation and persistence of glial cell
activation in Parkinsonism, we investigate the function of IFN-γ and TNF-α in experimental …
activation in Parkinsonism, we investigate the function of IFN-γ and TNF-α in experimental …
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
Polarized segregation of proteins in T cells is thought to play a role in diverse cellular
functions including signal transduction, migration, and directed secretion of cytokines …
functions including signal transduction, migration, and directed secretion of cytokines …