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Insights into persistent HIV-1 infection and functional cure: novel capabilities and strategies
Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …
Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
Socioeconomic status, lifestyle, and DNA methylation age among racially and ethnically diverse adults: NIMHD Social Epigenomics Program
Importance Variation in DNA methylation at specific loci estimates biological age, which is
associated with morbidity, mortality, and social experiences. Aging estimates known as …
associated with morbidity, mortality, and social experiences. Aging estimates known as …
Circulating brain-derived extracellular vesicles expressing neuroinflammatory markers are associated with HIV-related neurocognitive impairment
Background Neurocognitive impairment remains prevalent in people with HIV (PWH)
despite long term virological suppression by antiretroviral therapy (ART) regimens. Systemic …
despite long term virological suppression by antiretroviral therapy (ART) regimens. Systemic …
HIV infection of macrophages: implications for pathogenesis and cure
Although CD4+ T cells represent the major reservoir of persistent HIV and SIV infection,
accumulating evidence suggests that macrophages also contribute. However, investigations …
accumulating evidence suggests that macrophages also contribute. However, investigations …
Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality
Background The effects of tobacco smoking on epigenome-wide methylation signatures in
white blood cells (WBCs) collected from persons living with HIV may have important …
white blood cells (WBCs) collected from persons living with HIV may have important …
Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV
Background: Despite effective antiretroviral therapy, cognitive impairment and other aging-
related comorbidities are more prevalent in people with HIV (PWH) than in the general …
related comorbidities are more prevalent in people with HIV (PWH) than in the general …
Examining the immunoepigenetic-gut microbiome axis in the context of self-esteem among Native Hawaiians and other Pacific Islanders
CY Becerra, RK Wells, BP Kunihiro, RH Lee… - Frontiers in …, 2023 - frontiersin.org
Introduction: Native Hawaiian and other Pacific Islander (NHPI) populations experience
higher rates of immunometabolic diseases compared to other racial-ethnic groups in Hawaii …
higher rates of immunometabolic diseases compared to other racial-ethnic groups in Hawaii …
Epigenetic modulation of myeloid cell functions in HIV and SARS-CoV-2 infection
C Krause, E Bergmann, SV Schmidt - Molecular Biology Reports, 2024 - Springer
Myeloid cells play a vital role in innate immune responses as they recognize and
phagocytose pathogens like viruses, present antigens, produce cytokines, recruit other …
phagocytose pathogens like viruses, present antigens, produce cytokines, recruit other …