The ability to model human brain development in vitro represents an important step in our
study of developmental processes and neurological disorders. Protocols that utilize human …

Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

During vertebrate development, a wide variety of cell types and tissues emerge from a single
fertilized oocyte. One of these tissues, the central nervous system, contains many types of …

Long-term ex vivo live imaging combined with unbiased sampling of cycling precursors
shows that macaque outer subventricular zone (OSVZ) includes four distinct basal radial …