Advances and challenges toward develo** kidney organoids for clinical applications
R Nishinakamura - Cell Stem Cell, 2023 - cell.com
Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …
methods of generating the nephron lineage are well established, new protocols to induce …
The “3Ds” of growing kidney organoids: Advances in nephron development, disease modeling, and drug screening
BE Chambers, NE Weaver, RA Wingert - Cells, 2023 - mdpi.com
A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …
disease. We report a modified human kidney organoid system that generates thousands of …
Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types
Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and
collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe …
collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe …
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
Current kidney organoids model development and diseases of the nephron but not the
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …
3D Hydrogel Encapsulation Regulates Nephrogenesis in Kidney Organoids
Stem cell‐derived kidney organoids contain nephron segments that recapitulate
morphological and functional aspects of the human kidney. However, directed differentiation …
morphological and functional aspects of the human kidney. However, directed differentiation …
Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids
While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …
disease, the proximal nephron remains immature with limited evidence for key functional …
[HTML][HTML] Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma
S Tanigawa, E Tanaka, K Miike, T Ohmori… - Nature …, 2022 - nature.com
Organs consist of the parenchyma and stroma, the latter of which coordinates the generation
of organotypic structures. Despite recent advances in organoid technology, induction of …
of organotypic structures. Despite recent advances in organoid technology, induction of …
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids
FA Yousef Yengej, J Jansen… - Proceedings of the …, 2023 - National Acad Sciences
Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …
valuable for studies of kidney development, disease, and therapeutic screening. However …
A personalized glomerulus chip engineered from stem cell-derived epithelium and vascular endothelium
Progress in understanding kidney disease mechanisms and the development of targeted
therapeutics have been limited by the lack of functional in vitro models that can closely …
therapeutics have been limited by the lack of functional in vitro models that can closely …