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ACSL4-mediated ferroptosis and its potential role in central nervous system diseases and injuries
B Jia, J Li, Y Song, C Luo - International Journal of Molecular Sciences, 2023 - mdpi.com
As an iron-dependent regulated form of cell death, ferroptosis is characterized by iron-
dependent lipid peroxidation and has been implicated in the occurrence and development …
dependent lipid peroxidation and has been implicated in the occurrence and development …
Astrocytes: targets for neuroprotection in stroke
In the past two decades, over 1000 clinical trials have failed to demonstrate a benefit in
treating stroke, with the exception of thrombolytics. Although many targets have been …
treating stroke, with the exception of thrombolytics. Although many targets have been …
ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation
Y Cui, Y Zhang, X Zhao, L Shao, G Liu, C Sun… - Brain, behavior, and …, 2021 - Elsevier
Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for
polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role …
polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role …
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce …
Y Deng, R Duan, W Ding, Q Gu, M Liu, J Zhou… - Cell death & …, 2022 - nature.com
Acute ischemic stroke (AIS) is a global cerebrovascular disease with high disability and
mortality, which has no effective therapy. Studies have demonstrated that astrocyte-derived …
mortality, which has no effective therapy. Studies have demonstrated that astrocyte-derived …
LncRNA MALAT1 silencing protects against cerebral ischemia-reperfusion injury through miR-145 to regulate AQP4
H Wang, X Zheng, J **, L Zheng, T Guan… - Journal of biomedical …, 2020 - Springer
Background The present study aimed to verify whether long noncoding RNA (lncRNA)
MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to …
MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to …
[HTML][HTML] Down-regulation of Lncrna MALAT1 attenuates neuronal cell death through suppressing Beclin1-dependent autophagy by regulating Mir-30a in cerebral …
D Guo, J Ma, L Yan, T Li, Z Li, X Han… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: LncRNA metastasis associated lung adenocarcinoma transcript 1
(MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke …
(MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke …
LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p/ROCK1
Y Zhong, C Yu, W Qin - Cancer gene therapy, 2019 - nature.com
Recently, long non-coding RNAs (lncRNAs) are considered as critical regulators in
pathogenesis progression of cerebral ischemia. In present study, lncRNA-small nucleolar …
pathogenesis progression of cerebral ischemia. In present study, lncRNA-small nucleolar …
Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia
Abstract miR-181 has deleterious effects on stroke outcome, and reducing miR-181a levels
prior to middle cerebral artery occlusion (MCAO) was shown previously to be protective …
prior to middle cerebral artery occlusion (MCAO) was shown previously to be protective …
microRNAs: innovative targets for cerebral ischemia and stroke
YB Ouyang, CM Stary, GY Yang… - Current drug targets, 2013 - ingentaconnect.com
Stroke is one of the leading causes of death and disability worldwide. Because stroke is a
multifactorial disease with a short therapeutic window many clinical stroke trials have failed …
multifactorial disease with a short therapeutic window many clinical stroke trials have failed …
Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1
R Wei, L Zhang, W Hu, J Wu, W Zhang - Experimental neurology, 2019 - Elsevier
Emerging evidence has suggested a significant role of long non-coding RNAs (lncRNAs) in
ischemic stroke by acting as competing endogenous RNAs (ceRNAs) for microRNAs …
ischemic stroke by acting as competing endogenous RNAs (ceRNAs) for microRNAs …