Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Analysis and systematization of accumulated data on carbohydrate structural diversity is a
subject of great interest for structural glycobiology. Despite being a challenging task …

One of the main obstacles in prevention and treatment of COVID-19 is the rapid evolution of
the SARS-CoV-2 Spike protein. Given that Spike is the main target of common treatments of …

Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and
prolonged ER stress leads to cell apoptosis. Despite increasing research in this area, the …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional ligands that mediate the
interaction between a protein target and an E3 ligase, resulting in a ternary complex, whose …

In recent years, the observed antibody sequence space has grown exponentially due to
advances in high-throughput sequencing of immune receptors. The rise in sequences has …

The computational modeling field has vastly evolved over the past decades. The early
developments of simplified protein systems represented a step** stone towards …

The transport activity of the sarco (endo) plasmic reticulum calcium ATPase (SERCA) in
cardiac myocytes is modulated by an inhibitory interaction with a transmembrane peptide …

Biomolecular structure drives function, and computational capabilities have progressed such
that the prediction and computational design of biomolecular structures is increasingly …

Most of the protein–protein docking methods treat proteins as almost rigid objects. Only the
side-chains flexibility is usually taken into account. The few approaches enabling docking …