Targeting microbial biofilms: current and prospective therapeutic strategies

H Koo, RN Allan, RP Howlin, P Stoodley… - Nature Reviews …, 2017 - nature.com
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …

Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

[HTML][HTML] Phage therapy: An alternative to antibiotics in the age of multi-drug resistance

DM Lin, B Koskella, HC Lin - World journal of gastrointestinal …, 2017 - ncbi.nlm.nih.gov
The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial
infections, has been around for almost a century. The universal decline in the effectiveness …

Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

Targeting biofilms therapy: current research strategies and development hurdles

Y Jiang, M Geng, L Bai - Microorganisms, 2020 - mdpi.com
Biofilms are aggregate of microorganisms in which cells are frequently embedded within a
self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other …

Lactic acid bacteria isolated from dairy products as potential producers of lipolytic, proteolytic and antibacterial proteins

I García-Cano, D Rocha-Mendoza… - Applied microbiology …, 2019 - Springer
Regular consumption of fermented dairy products helps maintain a healthy microbiota and
prevent gut dysbiosis-linked diseases. The lactic acid bacteria (LAB) present in food …

Recombinant endolysins as potential therapeutics against antibiotic-resistant Staphylococcus aureus: current status of research and novel delivery strategies

H Haddad Kashani, M Schmelcher… - Clinical microbiology …, 2018 - Am Soc Microbiol
Staphylococcus aureus is one of the most common pathogens of humans and animals,
where it frequently colonizes skin and mucosal membranes. It is of major clinical importance …

Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

B Maciejewska, T Olszak, Z Drulis-Kawa - Applied microbiology and …, 2018 - Springer
Bacteriophages (phages) are viruses that infect bacteria. The “predator–prey” interactions
are recognized as a potentially effective way to treat infections. Phages, as well as phage …

L-form conversion in Gram-positive bacteria enables escape from phage infection

JC Wohlfarth, M Feldmüller, A Schneller, S Kilcher… - Nature …, 2023 - nature.com
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …