Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics
in the heart. Whereas mechanical activity is usually seen as 'the endpoint'of cardiac auto …

Our current understanding of cardiac excitation and its coupling to contraction is largely
based on ex vivo studies utilising fluorescent organic dyes to assess cardiac action …

Cardiac arrhythmias are among the most challenging human disorders to diagnose and
treat due to their complex underlying pathophysiology. Suitable experimental animal models …

Chondroitin sulfate proteoglycans (CSPGs) inhibit sympathetic reinnervation in rodent
hearts post-myocardial infarction (MI), causing regional hypoinnervation that is associated …

Plenty of non-cardiovascular drugs alter cardiac electrophysiology and may ultimately lead
to life-threatening arrhythmias. In clinical practice, measuring the QT interval as a marker for …

The spine is one of the most common sites of bony metastases, and its involvement leads to
significant patient morbidity. Surgical management in these patients is aimed at improving …

Arrhythmic sudden cardiac death (SCD) is an important cause of mortality following
myocardial infarction (MI). The rabbit has similar cardiac electrophysiology to humans and is …

Aims Although voltage-sensitive dye di-4-ANEPPS is a common tool for map** cardiac
electrical activity, reported effects on electrophysiological parameters are rather. The main …

Myocardial microstructure and its macroscopic materialisation are fundamental to the
function of the heart. Despite this importance, characterisation of cellular features at the …

Several studies suggest QT prolongation and torsade de pointes with acetylcholine-esterase
inhibitors. We therefore examined the electrophysiologic profile of donepezil, rivastigmine …