ATP-sensitive potassium channelopathies: focus on insulin secretion
FM Ashcroft - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
ATP-sensitive potassium (KATP) channels, so named because they are inhibited by
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …
Activating mutations in Kir6. 2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc
Closure of ATP-sensitive K+ channels (KATP channels) in response to metabolically
generated ATP or binding of sulfonylurea drugs stimulates insulin release from pancreatic β …
generated ATP or binding of sulfonylurea drugs stimulates insulin release from pancreatic β …
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6. 2 and permanent neonatal diabetes
AL Gloyn, ER Pearson, JF Antcliff, P Proks… - … England Journal of …, 2004 - Mass Medical Soc
Background Patients with permanent neonatal diabetes usually present within the first three
months of life and require insulin treatment. In most, the cause is unknown. Because ATP …
months of life and require insulin treatment. In most, the cause is unknown. Because ATP …
KATP channels and islet hormone secretion: new insights and controversies
FM Ashcroft, P Rorsman - Nature Reviews Endocrinology, 2013 - nature.com
ATP-sensitive potassium channels (KATP channels) link cell metabolism to electrical activity
by controlling the cell membrane potential. They participate in many physiological processes …
by controlling the cell membrane potential. They participate in many physiological processes …
ATP-Sensitive potassium channels and their physiological and pathophysiological roles.
ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …
Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?
JC Florez - Diabetologia, 2008 - Springer
Although type 2 diabetes has been traditionally understood as a metabolic disorder initiated
by insulin resistance, it has recently become apparent that an impairment in insulin secretion …
by insulin resistance, it has recently become apparent that an impairment in insulin secretion …
Monogenic diabetes: what it teaches us on the common forms of type 1 and type 2 diabetes
Y Yang, L Chan - Endocrine reviews, 2016 - academic.oup.com
To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
Neonatal diabetes mellitus
L Aguilar-Bryan, J Bryan - Endocrine reviews, 2008 - academic.oup.com
An explosion of work over the last decade has produced insight into the multiple hereditary
causes of a nonimmunological form of diabetes diagnosed most frequently within the first 6 …
causes of a nonimmunological form of diabetes diagnosed most frequently within the first 6 …
Long-chain acyl-CoA esters in metabolism and signaling: role of acyl-CoA binding proteins
D Neess, S Bek, H Engelsby, SF Gallego… - Progress in lipid …, 2015 - Elsevier
Long-chain fatty acyl-CoA esters are key intermediates in numerous lipid metabolic
pathways, and recognized as important cellular signaling molecules. The intracellular flux …
pathways, and recognized as important cellular signaling molecules. The intracellular flux …
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region
The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its associated islet
ATP-sensitive potassium channel (Kir6. 2; encoded by KCNJ11) are adjacent to one another …
ATP-sensitive potassium channel (Kir6. 2; encoded by KCNJ11) are adjacent to one another …