Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y **a, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics

H Hampel, A Elhage, M Cho, LG Apostolova… - Brain, 2023 - academic.oup.com
Excess accumulation and aggregation of toxic soluble and insoluble amyloid-β species in
the brain are a major hallmark of Alzheimer's disease. Randomized clinical trials show …

Global estimates on the number of persons across the Alzheimer's disease continuum

A Gustavsson, N Norton, T Fast, L Frölich… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …

Biomarkers in Alzheimer's disease: role in early and differential diagnosis and recognition of atypical variants

B Dubois, CAF von Arnim, N Burnie, S Bozeat… - Alzheimer's Research & …, 2023 - Springer
Background Development of in vivo biomarkers has shifted the diagnosis of Alzheimer's
disease (AD) from the later dementia stages of disease towards the earlier stages and has …

The amyloid-β pathway in Alzheimer's disease

H Hampel, J Hardy, K Blennow, C Chen, G Perry… - Molecular …, 2021 - nature.com
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

TK Karikari, NJ Ashton, G Brinkmalm… - Nature Reviews …, 2022 - nature.com
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …

Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

B Dubois, N Villain, GB Frisoni, GD Rabinovici… - The Lancet …, 2021 - thelancet.com
Summary In 2018, the US National Institute on Aging and the Alzheimer's Association
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …

Precuneus magnetic stimulation for Alzheimer's disease: a randomized, sham-controlled trial

G Koch, EP Casula, S Bonnì, I Borghi, M Assogna… - Brain, 2022 - academic.oup.com
Repetitive transcranial magnetic stimulation (rTMS) is emerging as a non-invasive
therapeutic strategy in the battle against Alzheimer's disease. Alzheimer's disease patients …

Multimodal deep learning models for early detection of Alzheimer's disease stage

J Venugopalan, L Tong, HR Hassanzadeh… - Scientific reports, 2021 - nature.com
Most current Alzheimer's disease (AD) and mild cognitive disorders (MCI) studies use single
data modality to make predictions such as AD stages. The fusion of multiple data modalities …

Blood‐based biomarkers for Alzheimer's disease

A Leuzy, N Mattsson‐Carlgren, S Palmqvist… - EMBO molecular …, 2022 - embopress.org
Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public
health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …