In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

Abstract The Global Burden of Disease report of 2019 estimated 14 million infection‐related
deaths, making it the second leading cause of death after ischaemic heart disease. Bacterial …

Antimicrobial resistance is a leading cause of mortality, calling for the development of new
antibiotics. The fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks …

Antimicrobial resistance remains a significant global threat, driving up mortality rates
worldwide. Ribosomally synthesized and post-translationally modified peptides have …

We are now moving into the antimicrobial resistance (AMR) era where more antibiotic
resistant bacteria are now the majority, a problem brought on by both misuse and over use …

The discoveries of penicillin and streptomycin were pivotal for infection control with the
knowledge subsequently being used to enable the discovery of many other antibiotics …

In recent years, antibiotic therapy has encountered significant challenges due to the rapid
emergence of multidrug resistance among bacteria responsible for life‐threatening …

Cyclic peptides offer a range of notable advantages, including potent antibacterial
properties, high binding affinity and specificity to target molecules, and minimal toxicity …

Natural products with antibacterial activity are highly desired globally to combat against
multidrug-resistant (MDR) bacteria. Antibacterial peptide (ABP), especially cyclic ABP …

This Feature Article discusses recent advances in the development of cascade ring
expansion reactions for the synthesis of medium-sized rings and macrocycles. Cascade ring …