The peptidases of Trypanosoma cruzi: digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death

VE Alvarez, GT Niemirowicz, JJ Cazzulo - Biochimica et Biophysica Acta …, 2012 - Elsevier
Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains
cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among …

Plant kunitz inhibitors and their interaction with proteases: Current and potential pharmacological targets

CR Bonturi, AB Silva Teixeira, VM Rocha… - International Journal of …, 2022 - mdpi.com
The action of proteases can be controlled by several mechanisms, including regulation
through gene expression; post-translational modifications, such as glycosylation; zymogen …

[HTML][HTML] A novel subclassification for Kunitz proteinase inhibitors from leguminous seeds

MLV Oliva, MCC Silva, RC Sallai, MV Brito… - Biochimie, 2010 - Elsevier
Kunitz-type trypsin inhibitors from legume seeds have been characterized structurally. The
presence of Cys–Cys in single or double chains shows a new pattern of proteins structurally …

Functional analysis of the Kunitz trypsin inhibitor family in poplar reveals biochemical diversity and multiplicity in defense against herbivores

IT Major, CP Constabel - Plant Physiology, 2008 - academic.oup.com
We investigated the functional and biochemical variability of Kunitz trypsin inhibitor (KTI)
genes of Populus trichocarpa× Populus deltoides. Phylogenetic analysis, expressed …

Revisiting the significance of natural protease inhibitors: A comprehensive review

DC Paul, M Bhattacharjee - International Journal of Biological …, 2024 - Elsevier
Protease inhibitors (PIs) function as a natural adversary to proteolytic enzymes. They can
diminish or inhibit the catalytic properties of proteases, which are crucial for various tasks in …

Seed storage protein, functional diversity and association with allergy

A Jain - Allergies, 2023 - mdpi.com
Plants are essential for humans as they serve as a source of food, fuel, medicine, oils, and
more. The major elements that are utilized for our needs exist in storage organs, such as …

Effects of a Peptide Derived from the Primary Sequence of a Kallikrein Inhibitor Isolated from Bauhinia bauhinioides (pep-BbKI) in an Asthma–COPD Overlap (ACO) …

LLS Silva, JAS Barbosa, JMLG João… - International Journal of …, 2023 - mdpi.com
(1) There are several patients with asthma–COPD overlap (ACO). A peptide derived from the
primary sequence of a kallikrein inhibitor isolated from Bauhinia bauhinioides (pep-BbKI) …

Physico-chemical and antifungal properties of protease inhibitors from Acacia plumosa

JLS Lopes, NF Valadares, DI Moraes, JC Rosa… - Phytochemistry, 2009 - Elsevier
This study was aimed at investigating the purification, biological activity, and some structural
properties of three serine protease inhibitors isoforms, denoted ApTIA, ApTIB, and ApTIC …

Plant protein proteinase inhibitors: structure and mechanism of inhibition

K S. Bateman, M NG James - Current Protein and Peptide …, 2011 - benthamdirect.com
This review outlines known examples of the three-dimensional structures of protein
proteinase inhibitors from plants. Three families of enzymes, serine proteinases …

Purification and biochemical characterization of a serine proteinase inhibitor from Derris trifoliata Lour. seeds: insight into structural and antimalarial features

A Bhattacharyya, CR Babu - Phytochemistry, 2009 - Elsevier
A potent serine proteinase inhibitor was isolated and characterized from the seeds of the
tropical legume liana, Derris trifoliata (DtTCI) by ammonium sulfate precipitation, ion …