Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative
studies have shown a certain correlation between the fluctuating abundance of Akkermansia …

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to
the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

The glucose metabolism is of major interest in all living mammals because certain vitally
important cell types (erythrocytes, brain cells, and kidney cells) have to rely on glucose as …

Elucidating the signalling mechanisms by which obesity leads to impaired insulin action is
critical in the development of therapeutic strategies for the treatment of diabetes. Recently …

The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid
and lipid metabolism. We show here that FXR plays a key regulatory role in glucose …

It is now widely accepted, given the current weight of experimental evidence, that reactive
oxygen species (ROS) contribute to cell and tissue dysfunction and damage caused by …

Increased incidence of several economically important diseases (ie mastitis, metritis,
displaced abomasum and ketosis) causes significant animal welfare problems and …

Scope: To determine the effect of consumption of a quercetin‐rich diet on obesity and
dysregulated hepatic gene expression. Methods and results: C56BL/6J mice were fed for 20 …

Transforming growth factor β (TGF-β) is a pluripotent cytokine that controls key tumour
suppressive functions,,, but cancer cells are often unresponsive to it,. The promyelocytic …