The fate of develo** T cells is specified by the interaction of their antigen receptors with
self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs) …

Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg)
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Understanding how thymic selection imparts self-peptide–MHC complex restriction and a
high degree of self tolerance on the T cell repertoire requires a detailed description of the …

The generation of regulatory T (T Reg) cells in the thymus is crucial for immune homeostasis
and self-tolerance. Recent discoveries have revealed the cellular and molecular …

The diversion of MHC class II-restricted thymocytes into the regulatory T (Treg) cell lineage
is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal …

Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by
clonal selection to protect the host from autoimmune pathology. It is now understood that the …

Regulatory T cells help maintain intestinal homeostasis by preventing inappropriate innate
and adaptive immune responses. CD4+ T cells that express Foxp3 and Tr1-like cells that …

Extracellular nucleotides are pleiotropic regulators of mammalian cell function. Adenosine
triphosphate (ATP) released from CD4+ helper T cells upon stimulation of the T cell receptor …

Stable expression of Foxp3 in regulatory T cells (Tregs) depends on DNA demethylation at
the Treg-specific demethylated region (TSDR), a conserved, CpG-rich region within the …